D-Asparagine Monohydrate
CAS 5794-24-1

Applications

1.Because numerous modern pharmaceuticals (such as antibiotics and antitumor drugs and so on) require accurate stereostructures, it is used in chiral drug synthesis as a chiral intermediate or a chiral synthesis unit. D-amino acids are not easily degraded by protease in the human body, so the drugs by the synthesis of D-amino acids usually have a longer half-life (slower metabolism, longer efficacy duration).

2.It is used to study enzyme specificity. Because numerous natural enzymes can only identify L-configuration, researchers utilize the D-configuration as a comparison or inhibitor to explore the biological reaction mechanism.

Advantages

FAQ

Q1：Why is the unit price of D-Asparagine so much higher than that of L-Asparagine?

A：Because of its scarcity of raw materials and synthesis costs. L-configuration is the amino acid that makes up proteins found in nature, which are produced on a large scale through fermentation, but D-configuration (non-natural amino acids) usually requires complex synthetic procedures or enzymatic resolution of the racemate. We provide D-configuration products are not only of high purity, but also offer clients highly competitive “chiral cost” through optimizing supply chain management.

Q2: How can the chiral identity of D-aspartamide be verified using a COA (Certificate of Analysis)?

A: The most straightforward index is specific optical rotation. D-Asparagine Monohydrate’s specific optical rotation shows a negative value (between -34.2° to -36.5°), but L-Asparagine Monohydrate shows a positive value. Most importantly, we always state direction and value of optical rotation, ensuring these products that you received are the 100% mirror-image enantiomers.

Q3. What are the core advantages of using D-Asparagine in biomedical research?

A: The core advantage lies in its biological stability. Since most protease can only recognize L-amino acids, incorporating D-Aspartamide into peptides or drug molecules makes them less prone to degradation by enzymes in the human body, thereby extending the metabolic half-life of drug (increasing the duration of drug efficacy). This makes it an ideal “chiral building block” for developing new antibiotics, anticancer drugs, and high-performance biomaterials.

Q4. How does Shandong Fulibai Chem Co., Ltd. control the residual L-isomers in D-configuration products?

A: We use precise chiral HPLC (High-performance liquid chromatography) for testing. Besides, we not only focus on chemical purity but also on the value of enantiomeric excess(ee). Shandong Fulibai Chem Co., Ltd. requires enantiomeric excess (ee) must maintain at≥99.5%, which means L-configuration residues are extremely low, guaranteeing that your research and development (R&D) experiments will not be subject to data bias caused by trace amounts of isomer interference.