L-Asparagine Monohydrate
CAS 5794-13-8

Applications

1.It is used in biomedicine and cell culture medium. L-Asparagine is an essential nitrogen source in cell culture medium when producing biopharmaceuticals on a large scale such as monoclonal antibodies,vaccines and so on. In conclusion, it has an effect on cell growth density and target protein expression level.

2.It is used for skincare products, which effectively locks the skin moisture while regulates skin metabolism by involving in the amino acid cycle within the skin. Besides, in anti-aging and physiological repair formulas,it can be combined with L-histidine dihydrochloride to jointly build a biomimetic skin natural moisturizing factor (NMF)as part of the skin barrier restoration regimen.

3.In research chemicals, it is used for proteomics research and biochemical synthesis, serving as a fundamental raw material for studying amino acid metabolic pathways.

4.In dietary supplements, as a premium dietary supplement ingredient, it helps accelerate ammonia metabolism (also called “eliminate ammonia toxicity”) in the body, relieves fatigue, reduces lactic acid accumulation, protect the myocardium and maintain the balance of brain neurotransmitters. 

Advantages

1.The specific rotation is controlled within the optimal range of +34.2°to +36.5°. We employ high-precision chiral analytical techniques to ensure the absolute purity of L-configuration and provide raw materials of “zero interference” for cutting-edge biotechnology research and development. 

2.In production process, we keep ammonium levels to a minimum (≤0.1%). Regarding cell culture grade products, we also provide low endotoxin batches to cater to the challenging environments in monoclonal antibody and vaccine production.

3.Each batch has always a rigorous transmittance test (≥98%), ensuring that the product presents a water-like clarity and transparency, without impurities or suspended solids after dissolution, thereby improving the quality of downstream products.

4.Shandong Fulibai Chem Co., Ltd. establishes a comprehensive batch record traceability system that whatever the time of purchase, the particle size distribution (PSD) and crystal form consistency of the materials remain stable, allowing clients to adjust manufacturing process parameters less frequently.

FAQ

Q1: How does Shandong Fulibai Chem Co., Ltd. ensure the safety of this product in cell culture applications?

A: In the application of biomedicine technology, endotoxin and microbial load are the key indicators. For biopharmaceutical-grade clients, we will provide high specification batches that controls endotoxin levels within an extremely low range through rigorous sterile filtration process and aseptic crystallization technology. Furthermore, testing for heavy metals (such as Lead, Mercury and Arsenic)exceeds standard industrial requirements to ensure the absolute purity of the cell culture environment.

Q2: Why are ammonium levels so crucial for this product?

A: Asparagine is prone to hydrolysis under improper production or storage conditions, resulting in the formation of ammonium salts. In the sensitive cells or high-precision chemical synthesis, a trace of ammonia may trigger cytotoxicity or interference-free reaction kinetics. Therefore, Shandong Fulibai Chem Co., Ltd. adopts a low -temperature purification process.We control the content of ammonium salts within the range of ≤0.1%, thereby ensuring the raw materials meet the demanding laboratory research and development requirements.

Q3: How to verify the chiral purity of L-Asparagine Monohydrate?

A: Because chiral purity is directly correlated with biological activity, we take a polarimetry to test specific rotation, ensuring the value lies precisely between +34.2° and +36.5°. Through physical constant analysis, we can completely exclude interference from the D-isomer, ensuring that the raw material supplied is 100% bioavailable in the L-configuration.

Q4. What are the unique advantages of this product in skincare formulations?

A: In addition to providing nourishment as a fundamental amino acid, L-Aspartamide Monohydrate excellets in enhancing the skin’s moisture retention capacity and regulating cellular metabolism. Due to its excellent moisture solubility and our products have a light transmittance of ≥98%, it doesn’t cause any precipitation or cloudiness in clear serums or aqueous formulations, thus significantly improving the sensory quality and stability of the end product.

Q5: What’s the packaging specification in Shandong Fulibai Chem Co., Ltd.? And how to ensure the crystal form stability in transnational long-haul shipping?

A: The packing specification is 25kg/drum (Double-layer HDPE moisture-proof inner bag),and we also provide small packaging for research grade, such as 1kg/bag.Because monohydrate contains water of crystallization,when temperature and humidity in ambient conditions fluctuate, the product may absorb moisture or lose its crystal water. Therefore, we use a pharmaceutical-grade aluminum foil bags with high moisture barrier properties in the packaging, combined with temperature-controlled warehousing, to ensure the products maintain consistent crystal form and prevent caking during long-haul ocean and air freight.