N-Carbobenzyloxy-D-alanine
CAS 26607-51-2

Applications

1. Chiral Pharmaceutical Synthesis：N-Cbz-D-alanine, as a high quality of chiral block, is widely applied in the manufacture of antibiotics, antiviral drugs and specific nucleoside analogues, as well as in the synthesis of high-grade enzyme inhibitors.

2. Peptide & Peptidomimetic Chains: In the artificial synthesis of peptidomimetic chains, it is used to introduce D-alanine structural units. Its N-terminal Cbz protecting group delivers excellent stability during the coupling stage, protecting the α-carbon from racemisation (chemical degradation) and minimising unwanted side reactions.

3. Fine Chemical & Biochemical Research: N-Cbz-D-alanine is widely used for asymmetric catalytic synthesis, high-throughput drug screening (HTS) and mechanistic study of specific cellular metabolic pathways in global top-tier clinical laboratories.

Advantages

1. Because any L-configurational impurities may affect the efficacy of the end-products, our products have a high value of the enantiomeric excess (the percentage of ee) that is crucial for clients who are located in downstream pharmaceuticals and luxury skincare products. 

2. Based on expertise with supply chains of basic chemical raw materials (such as alanine monomer and benzyl chloroformate and so on), we are able to optimize and reduce costs at the source, and most importantly, the fine chemical products are both high quality and competitively priced.

3. In the process of manufacture, we always strictly adhere to more detailed standards, and effectively control heavy metal residues, residual solvents (such as toluene and chloroform and so on) and microbial indicators, ensuring compliance with the market access requirements of major global markets.

4. Compared with other suppliers, we will hold a profound understanding of industry dynamics and market trends, and provide you direct and clear market forecasts and technical suggestions to help clients create a new product line in a short period.

FAQ

Q1: What’s the optical purity (e.e. value) of N-Benzyloxycarbonyl-D-alanine (N-Cbz-D-alanine) in your products? how do you prevent racemization during production?

A: The optical purity of chiral block is the lifeline of pharmaceutical materials.Our product’s enantiomeric excess (ee) is consistently ≥98%, as verified using a high-precision polarimeter and HPLC. Within the Cbz protection process, we adopt proprietary low-temperature esterification technology and regulate pH throughout, preventing α-carbon racemisation and ensuring structural consistency for downstream drug synthesis.

Q2: In structure-sensitive peptide synthesis,what is the optimal approach for Cbz protecting group cleavage?

A: Cbz protecting group is stable under conventional acid and alkaline conditions, yet in this specific reaction, it is cleaved cleanly and seamlessly.
Preferred Protocol: You should use palladium-carbon catalyzed hydrogenolysis (Pd/C + H₂) under ambient temperature conditions. This process cleaves the protecting group, which is quantitatively converted into volatile CO₂ and toluene, with no chemical residues remaining.
Recommended scale-up process: For large-scale production projects sensitive to hydrogen or with safety restrictions,it delivers high yields via transfer hydrogenation with ammonium formate or deprotection using HBr in acetic acid.

Q3: Facing regulatory audits by international pharmaceutical companies,how do you providecomplete technical support and purity chromatograms?

A: With the decade of international trade experience,we provide a full set of fully traceable compliance documentation package for each batch, including:
COA, HPLC, Specific rotation record curves and International standard compliant MSDS.
Besides, samples are regularly tested by independent third-party testing institutions, such as SGS and Eurofins, ensuring that heavy metals, residual solvents (e.g. toluene, chlorides) and water content comply with audit indicators for international pharmaceutical enterprises.

Q4:In order to prevent moisture absorption and degradation during international long-distance transportation,what’s your packaging specifications and storage agreement?

A:Because N-Benzyloxycarbonyl-D-alanine (N-Cbz-D-alanine) is sensitive to humidity and light, we adopt high-standard moisture-proof and light-shielding solution to ensure security for ocean and air freight worldwide.
Core packing: The inner layer adopts double-layer medical-grade PE liner bags, the outer layer adopts overwrapped with high-density light-proof aluminium foil bags. What’s more, desiccant is also placed inside, and the bags are heat-sealed under vacuum with nitrogen flushing to block moisture and oxygen. 
Outer reinforcement:The outermost layer uses fully sealed moisture-proof fibre drums,such as 1kg、5kg、25kg.
Storage Agreement: When receiving the products, please keep them protected from light in a cool and dry place.