Luteolin
CAS 491-70-3

Applications

1.In the brain health and neuroprotective supplements markets, luteolin is one of the rare natural flavonoids that can cross the blood-brain barrier. It curbs excessive activation of brain microglia and relieves chronic neuroinflammation brought on by long-term stress and viral infection. For these reasons, it is commonly blended into compound capsules to alleviate brain fog, sharpen focus and slow cognitive decline.Pharmacological research shows that luteolin delivers mild protective and calming benefits for the nervous system, so it is commonly blended with PEA or Quercetin to make premium dietary supplements targeting anxiety relief and neurasthenia improvement.

2.In respiratory care and anti-allergy support, luteolin suppresses the release of inflammatory factors such as IL-6 and TNF alpha to ease airway hyperresponsiveness. As a core active monomer, it is widely incorporated into nutraceuticals for asthma and chronic bronchitis, as well as daily lung health supplements for smokers.

3.In the functional skincare and anti-aging cosmeceutical applications, it absorbs UV rays and directly neutralizes UV-triggered free radicals, slowing collagen breakdown to deliver notable protection against photoageing and help fade sun-induced erythema.
For acute and chronic sensitive skin dermatitis and facial contact allergy, luteolin delivers fast calming action alongside antiredness and decongestant benefits. As a result, it is widely used in premium repair creams, anti allergy serums and post procedure specialist care masks.

Specifications

Advantages

1.Our luteolin purity remains at 93% (HPLC) via the advanced multi-stage column chromatography separation coupled with a recrystallization refining process, helping remove plant pigments such as Cotinus coggygria and Lonicera japonica. 

2.Using refined purification techniques, the finished product contains organic solvent residues well below the strictest international regulatory limits, with no detectable chlorinated hydrocarbon residues, complying with EU & US safety standards for premium dietary supplements as well as infant and sensitive skin topical skincare formulations.

3.In terms of aflatoxins, pesticide residues, PAHs and microbial limits, as well as heavy metal standards of lead, arsenic, mercury and cadmium, our luteolin meets requirements and well within the strict regulatory thresholds set by EFSA and FDA (such as Prop 65). 

4.We supply full COA, MSDS and TDS documentation. In addition, to satisfy audit requirements from renowned overseas brand customers, we arrange testing via globally accredited third party labs including SGS and Eurofins to deliver independent analytical reports.

FAQ

Q1: What is the purity of your Luteolin? And how about its appearance ?
A: Our luteolin is an active monomer with a minimum HPLC purity of ≥93%. Unlike conventional low-grade crude extracts available on the market, which range in colour from yellow-green to dark brown, our luteolin is refined through multi stage chromatographic separation and recrystallisation to form an exceptionally pure pale yellow to near off-white crystalline powder with virtually no characteristic herbal odour. In conclusion, this advantage ensures that when incorporated intopremium white creams, fully transparent serums or high grade capsules, it does not alter the colour or odour of finished products.

Q2: Which raw plants do you source luteolin from, and what solvents are adopted during production?
A: Our luteolin is exclusively extracted from premium medicinal raw materials including Cotinus coggygria and Lonicera japonica. In the production process, committed to green, safe and clean manufacturing standards, we utilize only purified water and food-grade ethanol as processing solvents across all extraction and purification steps and avoid toxic, hazardous chlorinated hydrocarbon or ester-based organic solvents including chloroform (trichloromethane) and ethyl acetate. In short, this process ensures that the end product contains organic solvent residues well below the strictest international regulatory limits, with no detectable chlorinated hydrocarbon residues, complying with EU & US safety standards for premium dietary supplements as well as infant and sensitive skin topical skincare formulations.

Q3: Why is it popular for supporting brain health and easing brain fog? And what is its mechanism of action?
A: Luteolin boasts a distinctive natural advantage in modern neuroprotection: it is among the few natural flavonoids capable of directly crossing the blood brain barrier (BBB). Modern medical research shows that prolonged stress, ongoing pressure or viral infections may overactivate brain microglia, triggering persistent neuroinflammation. This, in turn, causes issues like poor memory and poor concentration-commonly referred to as brain fog. Able to cross the blood brain barrier, luteolin suppresses inflammatory factors and safeguards neurons. As a valuable active monomer, it is commonly added to high-grade dietary supplements to relieve brain fog, slow cognitive decline, sharpen focus and balance mood.

Q4: What benefits does Luteolin offer in respiratory health and anti-allergy formulations?
A: It suppresses the release of inflammatory factors such as IL-6 and TNF alpha, which helps ease airway hyperresponsiveness. Beyond supporting those with asthma and chronic bronchitis, luteolin is also included in daily lung care supplements for smokers. It works by stabilising mast cells and blocking histamine at the source, making it a prime component in natural remedies for seasonal pollen allergies and allergic rhinitis.

Q5: In the skincare sector, what is the working principle of Luteolin for sensitive skin and anti - photoaging?
A: It absorbs UV rays and directly neutralizes UV-triggered free radicals, inhibits matrix metalloproteinase (MMP-1) from breaking down skin collagen, provides strong protection against photoageing and helps reduce sun-related erythema. For sensitive skin suffering from acute contact allergies, broken capillaries and seasonal allergic dermatitis, it delivers rapid redness relief, soothing action and skin barrier repair.As a result, it is widely used in premium repair creams, anti allergy serums and post procedure specialist care masks.