Alpha Lipoic Acid
CAS 1077-28-7

Applications

1.In the field of cosmetics and skincare, alpha-lipoic acid (ALA), a star ingredient for anti-glycation and dull yellow skin, is widely used in anti-aging serums, creams and eye creams. In addition, it precisely blocks the formation of advanced glycation end products (AGEs), protects collagen from cross-linking and degradation, minimizes pores visibly, smooths fine lines, and delivers full-thickness cellular defense against photoaging.

2.In the field of dietary supplements and weight management, alpha-lipoic acid (ALA) is popular in the wellness market. In the field of oral beauty supplements, it is often combined with glutathione and collagen to promote whole-body anti-glycation and skin brightening; in the field of metabolism and weight management, it significantly activates the AMPK enzyme, promoting the uptake of glucose into mitochondria for energy production, and is primarily used to stabilize blood sugar, accelerate fat burning, and combat fatigue.

3.In the field of pharmaceuticals and clinical health, as a high-purity, pharmaceutical-grade raw material, it is widely used to treat and alleviate diabetic peripheral neuropathy (DPN) and its complications. At the same time, due to its highly effective supportive and protective effects on the liver’s detoxification system, it is also commonly used overseas as the core active ingredient in medical-grade hangover relief and liver-protective intravenous drips (IV drips).

Specifications

Advantages

1.We adopt an innovative green recrystallization and aqueous-phase synthesis process, preventing high-toxic organic solvents from being used throughout the entire production process. Besides, the purity of alpha-lipoic acid (ALA) remains at ≥ 99% as verified by HPLC; individual impurity and total impurities are reduced to an extremely low level within the industry; and final product appears as a bright yellow crystalline powder with extremely low pungent odor through a multi-stage precision fractional crystallization technology. It is worth noting that we provide a complete residual solvents report, with all indicators far exceed the standards specified in international pharmacopoeias (USP/EP).

2.The particle structure of the powder is optimized via proprietary crystal morphology control and low-temperature spray drying modification technology. In addition, we can precisely customize products to 80-mesh, 100-mesh and micronized particle grades according to customers’ dosage form requirements. In conclusion, the thermal resistance, abrasion resistance and flowability of the powder are also improved.

3.We have a fine chemical workshop that complies with GMP standards, and our ton-scale monthly output ensures stable supply. What’s more, we also provide complete set of documents, such as TDS, MSDS and COA.

FAQ

Q1: What’s the purity of your alpha-lipoic acid (ALA)? How are residual solvents controlled?

A: We adopt an innovative environmentally friendly non-toxic recrystallization technology, ensuring the purity of alpha-lipoic acid is ≥ 99% as verified by HPLC, and our alpha-lipoic acid complies with premium quality specifications. In conclusion, the end products achieve no detectable toxic residual solvents, meeting the rigorous clean label criteria and safety regulatory requirements of premium global nutrition and cosmetic brands.

Q2: Alpha-lipoic acid (ALA) has a relatively low melting point, it will turn sticky and clog processing equipment during capsule filling, so how do you solve the problem?

A: Conventional alpha-lipoic acid has a relatively low melting point (approximately 60-62℃), it will cause the powder to melt, turn sticky, form agglomerates and lead to machine shutdown during capsule filling or tableting. In order to solve the problem, we adopt proprietary low-temperature crystal form modification technology, optimizing particle morphology, surface thermal resistance and abrasion resistance of the powder. Fortunately, the crystal-modified powder has excellent flowability and process adaptability, eliminating residual material adhesion to equipment and improving production rate.

Q3: Unmodified alpha-lipoic acid emits a strong pungent sulfur odor, how do you solve the problem?

A: This strong pungent sulfur odor is induced by unreacted chemical intermediates and sulfur-containing volatile impurities. In contrast, we adopt an advanced multi-stage fractional crystallization and aqueous-only washing process, which completely removes odor-causing impurities. Our material appears as clean bright yellow crystalline particles with extremely low and faint odor, therefore, formulators don’t need to add excessive flavor masking essences or flavoring agents in premium skincare and dietary supplements.

Q4:What is the scientific evidence to use Alpha-lipoic acid (ALA) in premium anti-aging skincare products and metabolic health supplements?

A: Alpha-lipoic acid (ALA) is known as the “all-round antioxidant”, which can penetrate all regions of cells without any barriers whether in aqueous or lipid environments, and scavenge free radicals in the entire cell. In cosmetics, it precisely blocks the formation of advanced glycation end products (AGEs), protects collagen from cross-linking and degradation, preventing skin yellowing and sagging. In nutritional supplements, it triggers adenosine monophosphate-activated protein kinase (AMPK), and facilitates glucose entry into the mitochondria for oxidative metabolism which is the key mechanism for supporting healthy blood glucose levels and weight management.