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COSMETIC INGREDIENTS

Allantoin
CAS:97-59-69900,43

Product Name Allantoin 
Molecular Formula C₄H₆N₄O₃
Molecular Weight 158.12
EINECS No 202-592-8
Appearance White Powder
Package 1kg/5kg Aluminum foil bag 25kg/Drum 25kg/Carton or customized as per customer's requirements
Storage Store in a cool, dry place, tightly sealed, away from heat and light
MOQ 1 KG
Payment T/T, LC or DA
Delivery Time Ready Stock in Local Warehouse, 1-3 days
Origin China
Shipping DHL, FedEx, TNT, EMS, By Sea, By Air 

Description

Allantoin is a classic and highly effective skin-conditioning and active ingredient. Therefore, it is widely used in cosmetics and personal care products, such as creams, toners, masks, toothpaste, and baby care products.

Applications

Core efficacies of Allantoin:
First, it can promote cell renewal and accelerates wound healing. Notably, allantoin is well-known for boosting epidermal cell growth and tissue repair. It is widely included in medical ointments to support wound healing. In skincare formulations, it can accelerate the repair of minor skin damage and soothe impaired skin barrier.
Second, it provides outstanding soothing and anti-irritant effects. It relieves stinging, redness and skin irritation induced by environmental stressors, UV rays and harsh actives such as acids and retinoids, making it a key component in soothing, skin-restoring formulations.
Third, it delivers excellent moisturizing and keratolytic effects. Allantoin, a dual-action humectant, draws moisture from ambient air and locks it onto the skin surface. It delivers mild keratin-softening effects that support gentle desquamation of dead keratinocytes, leaving the skin noticeably smoother and finer.
Applications:
First, it features favourable safety and tolerability. Allantoin exhibits high safety and good stability, and virtually causes no skin irritation or sensitisation. It has undergone numerous international safety evaluations, so it is widely used in formulations for sensitive skin and infant care.
Second, within cosmetic formulations, it synergises with niacinamide, hyaluronic acid, plant extracts and diverse acids to deliver the "burden-reducing, efficacy-boosting" effect. It can not only boost overall efficacy, but also mitigate potential irritation.
Third, it possesses high commercial value. As a fundamental yet indispensable functional ingredient, allantoin boasts a wide range of applications. It is regarded as a staple skincare raw material featuring high cost-effectiveness, steady market demand and long-standing market presence.

Advantages

First, in terms of cost and production scalability, Chinese suppliers deliver superior cost-effectiveness versus overseas suppliers, thanks to large-scale production, bulk raw-material purchasing and streamlined cost control.
Second, with optimized crystallization process and mother-liquor recovery technology within modern fine-chemical production facilities, purity can be controlled within 98.5% to 99.5% or higher. Residual indexes including heavy metals (e.g. lead, arsenic) and chlorides are also tightly controlled, fully satisfying stringent cosmetic-grade requirements for low irritation and low residual levels.
Third, in terms of stability and physico-chemical properties, allantoin features resistance to caking, discoloration and degradation thanks to well-developed synthetic processes. Such properties hold under ambient temperature and humidity, giving it excellent shelf-life stability.
Fourth, in terms of green-manufacturing workflows, continuous optimizations are carried out for mother-liquor recycling as well as wastewater and waste-gas treatment to realize cleaner production throughout the manufacturing process.

FAQ

Q1: What is the typical usage level of Allantoin in cosmetics?
A: The typical usage level ranges from 0.1% to 0.5%. For high-efficacy repairing, soothing and anti-irritant, or special-care formulations, the recommended dosage may be adjusted based on formulation requirements (Note: the safe upper limit is generally up to 2.0%). This raw material is skin-gentle and compatible with most skin types.
Q2: How soluble is Allantoin? Is it easy to handle in formulations?
A: In ambient-temperature water, the solubility of allantoin is approximately 0.5 % at 20°C. It is sparingly soluble in cold water, and soluble in hot water, ethanol and glycerin, while insoluble in ether and chloroform. For practical processing, disperse allantoin in water at 75-80 °C under stirring until fully dissolved, then incorporate the other formulation ingredients. It should be noted that when processing at low formulation temperatures, pre-calculate the water dosage to guarantee full dissolution and prevent crystallization within the finished product.
Q3: Will Allantoin conflict with other active ingredients such as acids, niacinamide or retinol in a formulation?
A: No. Instead, synergistic benefits may be achieved. Allantoin features high stability together with outstanding anti-irritant and soothing properties. It is commonly combined with retinoids, AHAs, BHAs, niacinamide and other actives to reduce irritation and redness and enhance the overall comfort of finished products.
Q4: How may I request free samples for lab testing?
A: We welcome and support formulation testing and provide free laboratory samples to qualified partners with real needs. Generally speaking, the sample itself is free, while the international express shipping, such as DHL or FedEx, is the purchaser’s responsibility. Please provide your shipping address and requirements, and we will arrange dispatch along with complete technical data.
Q5: Does Allantoin impose pH requirements? Is it stable across formulations?
A: Allantoin has excellent chemical stability. It remains stable over a wide pH range from about 3.0 to 8.0, well-suited for most skincare systems on the market, such as mildly acidic toners, neutral creams, mild cleansers. Most importantly, within the recommended pH range, it does not hydrolyze or lose efficacy.

Regulatory compliance

China: It is listed in the Inventory of Cosmetic Raw Materials Used (2023 edition) acted by NMPA. Besides, it is a legally conventional raw material that does not require new ingredient registration or filing.
European Union: As a conventional usable ingredient, it is not restricted or restricted-use prohibitions in Annexes to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products.
United States: It is a legally conventional raw material that does not require pre-market FDA approval. Besides, it is not a colorant nor an OTC active drug ingredient.
Japan: It is listed in the Japanese Standards of Cosmetic Ingredients (JSCI) as a conventionally permitted cosmetic ingredient.
Canada: It is not restricted by the Cosmetic Ingredient Hotlist, making it a legally permitted conventional cosmetic ingredient.
Australia: It is listed in Australian Inventory of Industrial Chemicals (AIIC) as a legally conventional raw material.

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