Nicotinamide Riboside Chloride
（NR-Cl）CAS 23111-00-4

Applications

1.In the field of metabolic health and cardiovascular health supplements, nicotinamide riboside chloride (NR-Cl) activates intracellular mitochondria, so it is widely used to produce dietary supplements, which helps regulate glucose metabolism, improve fatty liver conditions, and support healthy weight management by boosting fat metabolism.

2.In the field of anti-aging, healthspan management and chronic fatigue relief, because nicotinamide riboside chloride (NR-Cl) effectively elevates intracellular NAD⁺ levels, it can fully activate sirtuins and assist PARP enzymes in repairing DNA damage caused by daily ultraviolet exposure and environmental radiation.

3.In the field of neuroprotection, brain health and brain fog relief, nicotinamide riboside chloride (NR-Cl) suppress low-grade chronic inflammation in astrocytes that is triggered by aging and stress. Therefore, it is used to produce premium brain nutritional formulations, alleviating brain fog, supporting long-term memory, and preventing age-related cognitive decline in middle-aged and elderly populations.

4.In the field of functional skincare and advanced photodynamic skincare, topically applied nicotinamide riboside chloride (NR-Cl) can penetrate the epidermal basal layer of the skin, absorb UV rays and neutralize free radicals induced by UV rays, and inhibit skin collagen degradation caused by photodamage. Therefore, it is incorporated into premium anti-aging day creams, firming night creams and sun repair serums. In addition, it regulates melanocyte metabolism and helps brighten skin tone. It is worth noting that it helps boost the regeneration of basal cells, which provides auxiliary repairing effects for seasonal allergic dermatitis and redness and swelling after aesthetic photoelectric treatments.

Specifications

Advantages

1. Produced via an optimized specialized salt-forming and crystallization process, our product exists as a chloride salt form (NR-Cl) with a highly stable chemical structure.

2.In the step of upstream extraction and synthesis, a bioenzymatic catalytic process is adopted. In the whole process, there are no residual toxic industrial solvents such as chloroform and ethyl acetate. In addition, it appears as a white to off-white fine crystalline powder with virtually no odor; the purity of nicotinamide riboside chloride (NR-Cl) remains at 98% as verified by HPLC, satisfying high industry standards.

3.We offer COA, MSDS and TDS that comply with the highest international standards. In addition, the heavy metals and microorganisms are stricter than the requirements set by the European Food Safety Authority (EFSA) and California Proposition 65 of the United States.

FAQ

Q1: What is the purity of your nicotinamide riboside chloride (NR-Cl)? Why is it better suited for formulation development than conventional NR?
A: It appears as a white crystalline powder, and the purity remains at 98% as determined by HPLC. Produced via an optimized specialized salt-forming and crystallization process, our product exists as a chloride salt form (NR-Cl) with a highly stable chemical structure, which exhibits good stability under ambient temperature and high-humidity conditions. What’s more, it does not undergo degradation or phase separation, as well as formulation discoloration in aqueous solutions, capsule fills or cream bases.

Q2: What process is adopyed for nicotinamide riboside chloride (NR-Cl)? How to guarantee no toxic solvent residues in the finished product?
A: We adopt a fully biocatalytic enzymatic process, wherein its extraction and synthesis steps mimic endogenous biosynthetic pathways within the human body. No residual toxic industrial solvents such as chloroform and ethyl acetate are present throughout the purification process. As a result, the final product satisfies high industry standards, appearing as a white to off-white fine crystalline powder with virtually no odor. The product has been tested by independent authoritative third-party laboratories including SGS and Eurofins, demonstrating favorable safety profiles, which is suitable for long-term oral administration at high dosages as well as topical application for sensitive skin.

Q3: In the global anti-aging raw material market, what are the core differentiated competitive advantages of nicotinamide riboside chloride (NR-Cl) compared with NMN?
A: Both nicotinamide riboside chloride (NR-Cl) and NMN work primarily to elevate intracellular NAD⁺ levels in the human body, but nicotinamide riboside chloride (NR-Cl) is a monomer in the NAD⁺ supplement category with the most comprehensive human clinical trial data. It is worth noting that it is supported by clinical data from numerous internationally recognized clinical medical data, possessing strong medical credibility and substantial brand premium, especially in relieving symptoms of metabolic aging (including supporting healthy glycemic metabolism and improving fatty liver status), safeguarding cardiovascular endothelial cells, and maintaining vascular elasticity. Furthermore, it penetrates cell membranes via direct transport pathways, making it the preferred core active ingredient for premium formulations positioned around cardiovascular rejuvenation and mitochondrial energy replenishment due to its smaller molecular weight.

Q4: In the efficacy skincare sector, what is the mechanism of nicotinamide riboside chloride (NR-Cl) against photoaging and for skin barrier remodeling?
A: First of all, topically applied nicotinamide riboside chloride (NR-Cl) can penetrate the epidermal basal layer of the skin. Secondly, in anti-photoaging sectors, it can absorb UV rays and specifically neutralize free radicals induced by UV exposure, which inhibits skin collagen degradation caused by photodamage, thereby alleviating skin sagging and sun-induced erythema. In addition, it boosts intracellular NAD⁺ levels in epidermal cells and promotes the regeneration of basal cells, which provides auxiliary repairing effects for seasonal allergic dermatitis and redness and swelling after aesthetic photoelectric treatments.