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NUTRITION INGREDIENTS

Alpha GPC
CAS 28319-77-9

Product Name Alpha GPC
Other Name Alpha GPC (Choline Glycerophosphate)
CAS No. 28319-77-9
EINECS No. 248-962-2
Purity 98%
Molecular Formula C₈H₂₀NO₆P
Appearance White powder
Packaging 1kg/5kg Aluminum foil bag, 25kg/Drum, 25kg/Carton, or customized as per customer's requirements
Storage Conditions Store in a cool, dry place, tightly sealed, away from heat and light
Minimum Order Quantity (MOQ) 1 KG
Payment Terms T/T, LC, or DA
Delivery Time Ready Stock in Local Warehouse, 1–3 days
Country of Origin China
Shipping Methods DHL, FedEx, TNT, EMS, By Sea, By Air

Description

Choline Glycerophosphate (Alpha-GPC) is a water-soluble phospholipid metabolite naturally occurring in the human body, which serves as an efficient endogenous choline donor. Within the wellness and nootropics market, it is primarily used for cognitive enhancement and improvement of athletic explosive power. It can efficiently cross the blood-brain barrier and directly elevate acetylcholine levels in the brain, thereby improving memory and focus while stimulating growth hormone secretion.

Applications

1.In the field of brain health supplements, Brain Health Supplements: Choline Glycerophosphate (Alpha-GPC) is widely incorporated into various cognitive health dietary supplements, including cognitive support capsules, exam support nutritional formulations and brain fog relief granules. Its core functions are to improve cognitive efficiency, strengthen working memory and boost concentration. In mainstream nootropic stacks formulated in Europe and North America, it serves as a core foundational ingredient, which can alleviate cognitive decline induced by chronic fatigue and mental sluggishness caused by jet lag, while helping slow cognitive decline in middle-aged and elderly populations.

2.In the field of elite sports nutrition and power formulas, choline glycerophosphate is widely incorporated into pre-workout supplements, mass gainers, and explosive-strength supplements for professional athletes. Its mechanism of action falls into two categories. On the one hand, it enhances the mind-muscle connection via the central nervous system, which boosts maximal strength output; on the other hand, it can significantly stimulate acute secretion of human growth hormone (HGH) post-workout, thus accelerating physical recovery and promoting lean body mass gain.

3.In the field of medical nutrition and neuroprotection, as a high-purity, pharmaceutical-grade nutritional raw material, choline glycerophosphate is suitable for Foods for Special Medical Purposes (FSMP) designed to aid recovery from Alzheimer’s disease, vascular dementia and post-stroke sequelae. It preserves neuronal axon integrity by restoring cell membrane phospholipids and safeguards microcirculation in the central nervous system.

Specifications

Test Specifications
Appearance Viscous, transparent, colorless or lightly colored liquid. Partial crystallization in the process of storage is permissible.
Solubility Very or freely soluble in water, freely soluble in 96% ethanol.
Identification • The IR spectrum is similar to that of Glycerophosphorylcholine reference standard.
• TLC: The main spot in the chromatogram obtained for the sample solution is similar in position to the main spot in the chromatogram obtained for the reference solution.
• Positive reaction for phosphates.
Clarity 25% aqueous solution of the substance should be transparent.
Colour 25% aqueous solution of the substance should be colorless.
Specific Optical Rotation (on anhydrous basis) From –2.0 to –3.5
pH (25% m/V aqueous solution) 5.0 – 7.0
Impurities • Total content of impurities: not more than 4.0%
• Content of a single impurity: not more than 4.0%
Heavy Metals Not more than 10 ppm
Water (K. Fisher method) 13.0 – 20.0%
Residual Organic Solvents (Ethanol) Max. 5000 ppm
Assay (on anhydrous basis), by HPLC ≥ 98.5%
Bacterial Endotoxins NMT 0.35 EU/mg
TAMC & TYMC (in total) Not more than 10² in 1 g or in 1 mL
Enterobacteriaceae Absent in 1 g or in 1 mL
P. aeruginosa Absent in 1 g or in 1 mL
S. aureus Absent in 1 g or in 1 mL

Advantages

1. Through our in-house proprietary microencapsulation and anti-hygroscopic crystal nucleus control technology, we offer 50% choline glycerophosphate solid powder formulated with food-grade silica or other excipient carriers. The powder features uniform particle size and outstanding flowability. Manufactured under standard processes, our material delivers far superior moisture resistance compared ordinary alternatives and retains steady free-flowing characteristics throughout storage.

2.Our company produces 98% Alpha-GPC pure powder by adopting an automated closed-loop multi-stage membrane purification technology and low-toxicity aqueous crystallization process. The active ingredient content of the product, tested by High Performance Liquid Chromatography (HPLC), exceeds the requirements specified in international pharmacopoeia standards. It achieves undetectable levels of highly toxic solvents including dichloromethane and chloroform, while keeping the byproduct free choline at an extremely low concentration.

3.Our company operates modern ton-scale industrial production lines with stable monthly output capacity. And complete technical documentation and compliance dossiers are available for this product, and we hold multiple industry certifications.

FAQ

Q1: Choline Glycerophosphate (Alpha-GPC) made via traditional synthesis has toxic residual solvents. How about your material? Does it contain dichloromethane?
A: Safety and regulatory compliance are the minimum requirements. However, a large number of small-scale inferior factories use dichloromethane, chloroform and other harsh industrial solvents in order to boosts yields. That is the absolute non-negotiable standard in stringent international regulatory standards, such as Prop 65. Therefore, we utilize an advanced green catalytic synthesis process paired with multi-stage membrane filtration purification within an entirely aqueous system. Notably, no dichloromethane or other chlorinated volatile organic solvents were detected in our finished material; all gas chromatography (GC) test results are below the limit of detection (LOD). In addition, our products fully clear global toxicology audits for straightforward review by your QA and legal teams.

Q2: In addition to the nootropics sector, why does choline glycerophosphate (Alpha-GPC) play an essential role in elite sports nutrition and pre-workout formulas?
A: Because choline glycerophosphate (Alpha-GPC) likes a bridge between muscles and the brain--it is called the "Mind-Muscle Connection" in sports sciences. When taken before training, it rapidly optimizes neuromuscular signal transmission by elevating acetylcholine levels. Furthermore, it activates more muscle fibers to contract, directly boosting peak explosive power, bench press strength and agility during training. On top of that, multiple clinical studies show choline glycerophosphate (Alpha-GPC) triggers acute HGH release post-workout. This response speeds up muscle cell recovery, boosts fat breakdown via fatty acid oxidation, and helps users build greater lean body mass.

Q3: Could you provide standard international trade compliance documents and stable supply assurances for bulk purchasers?
A: Absolutely. We know about market access requirements of various countries based on over a decade of experience in the international trade of fine chemicals. Besides, we run large-scale industrial production lines to guarantee stable pricing and consistent monthly bulk supply. Each bulk order comes with a full set of technical documents, including TDS, MSDS and COA. What’s more, our products are 100% non-GMO and vegan, with complete Kosher and Halal certifications in place. All heavy metals (lead, arsenic, mercury, cadmium) are tightly restricted to less than 0.1 ppm, enabling hassle-free customs clearance worldwide and smooth QA/QC audit approvals.。

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