Apigenin
CAS 520-36-5

Applications

1.In the longevity market, apigenin is regarded as the “invisible guardian of NAD+”due to its unique ability to regulate enzymes.

2.In neuroprotection, profound sleep and emotional management, apigenin acts as a ligand that binds to brain GABA_A receptors. Generally speaking, this mechanism gently calms the central nervous system, lengthens deep sleep, and bypasses the tolerance and side effects of prescription sleep aids, making it well-suited for bedtime capsules and melatonin-alternative drinks.

3.In functional skincare and anti-aging cosmeceuticals, apigenin has a strong absorption capacity for UV rays. When applied topically, it neutralizes photodamage-related free radicals and inhibits MMP activity to prevent collagen breakdown, so it is widely used in sunscreens, daily creams and post-sun soothing products.

4.For urinary tract health and prostate care in men, apigenin exerts distinctive effects on epithelial cell growth, so it is widely formulated into functional food blends for middle-aged and elderly men, supporting prostate health by easing inflammation and preventing benign prostatic hyperplasia, while also sustaining healthy estrogen metabolism.

Specifications

Advantages

1. Our apigenin purity remains at ≥98% (HPLC) via the advanced multi-stage column chromatography separation coupled with a recrystallization refining process, helping remove chlorophyll and impurity pigments in raw herbs and forming an exceptionally pure pale yellow to near off-white crystalline powder with virtually no characteristic herbal odour.

2.Using refined purification techniques, the finished product contains organic solvent residues well below the strictest international regulatory limits, with no detectable chlorinated hydrocarbon residues, complying with EU & US safety standards for premium oral anti-aging supplements as well as infant and sensitiveskin topical skincare formulations.

3.In terms of aflatoxins, pesticide residues, PAHs and microbial limits, as well as heavy metal standards of lead, arsenic, mercury and cadmium, our apigenin meets requirements and exceeds the statutory limits set by EFSA and FDA (such as Prop 65).

4.High-purity Apigenin apigenin is a premium, state-of-the-art fine chemical ingredient. We understand that at the project launch phase, brands typically require 1kg–5kg of R&D-grade bulk material for pilot trials. With more than 10 years of expertise in international fine chemical trading, we are fully versed in customs procedures for non-hazardous goods and use aviation-standard packaging with superior light and moisture resistance. Most importantly, we deliver fast response and seamless customs clearance for both small air shipments and large sea freight consignments.

FAQ

Q1: What is the purity of your Apigenin? And will it lead to discoloration in the formula?

A: Our apigenin, an active monomer with HPLC purity of no less than 98%, is refined by multi-stage chromatographic separation and recrystallisation into an exceptionally pure pale yellow crystalline powder with barely any herbal odour. In conclusion, this advantage ensures that when incorporated into premium white creams, fully transparent serums or highgrade capsules, it has stable physical and chemical properties and does not alter the colour or odour of finished products.

Q2: Why is Apigenin regarded as the “invisible guardian of NAD+” in the premium Longevity market? And what is its mechanism?

A: Scientific research shows that with advancing age, CD38 enzyme levels in the body rise rapidly, causing a steep drop in cellular NAD+, known as the body’s “long-life fuel”. By contrast, apigenin is one of the most powerful CD38 inhibitors found in nature. When ingested, high-purity apigenin acts on CD38 to boost the body’s NAD+ reserves, with no extra exogenous burden. It blends excellently with NMN, resveratrol and urolithin A, all popular choices for premium mitochondrial and cellular anti-aging products.

Q3: How does apigenin work in sleep-aiding and emotional support supplements? Will it cause drug tolerance?

A: Pharmacological studies have identified that as a natural ligand, apigenin selectively attaches to GABA_A receptors in the brain. Its calming action on the nervous system helps stressed individuals sleep faster, extend deep sleep, and relieve anxiety and neuropathic headaches.

Q4: In functional skincare, what is the the core effect and mechanism of Apigenin on the skin?

A: Apigenin has a strong absorption capacity for UV rays. When applied topically, it neutralizes photodamage-related free radicals and inhibits MMP activity to prevent collagen breakdown. Besides, it can markedly lower the expression of inflammatory factors, delivering instant redness-reducing, soothing and barrier-repairing effects on sensitive skin with telangiectasia, seasonal facial redness and swelling, as well as skin damage after medical aesthetic photoelectric treatments.

Q5: What extraction solvents do you use during production? Can they meet the stringent quality inspection standards in EU and US?

A: We only use pure water and food-grade ethanol for all purification processes. No harmful solvents including chlorinated hydrocarbons, chloroform (trichloromethane) and ethyl acetate are used at any stage. As a result, organic solvent residues in the final bulk product stay far below global maximum limits. Being entirely free of chloroform, our product complies with all EU and US safety standards for premium dietary supplements and infant and sensitive-skin topical skincare.