Fisetin
CAS 528-48-3

Applications

1.In the anti-aging and life span management sectors, numerous “zombie cells (senescent cells)” are accumulated with aging in the human body. These cells stop dividing yet remain viable, constantly releasing inflammatory cytokines and accelerating the ageing of adjacent healthy cells. Scientific research shows that fisetin is one of the most effective natural senolytic ingredients, especially, its clearance efficiency even surpasses well-known quercetin. Therefore, it is widely used to produce high-concentration anti-aging capsules, or blended with quercetin and astragaloside IV, highlighting the concept of “Cellular Scavenger, Reverse Physiological Age”.

2.In brain wellness, cognitive enhancement and relief of brain fog markets, fisetin facilitates the growth of neuronal synapses and activates key synaptic signaling pathways. Besides, it shows remarkable effects on memory improvement and slowing cognitive decline in clinical studies. Because fisetin can inhibit brain microglial inflammation, it delivers excellent relief from brain fog caused by long-term high stress, chronic fatigue or viral infections, and helps refresh the mind.

3.For functional skincare and anti-aging cosmeceuticals,Topical application of fisetin works to remove senescent fibroblasts in the epidermis and dermis. It safeguards the collagen network to visibly improve laxity, sagging and long-standing dullness. It also curbs tyrosinase activity to inhibit melanin formation, plus delivers powerful broad-spectrum anti-inflammatory action to soothe capillary dilation, seasonal flushing and sun damage for sensitive skin.

Specifications

Advantages

1.At our upstream raw material base, we conduct rigorous selection of smoketree botanicals to completely eliminate harmful allergens. Besides, adopting multi-stage chromatographic separation and recrystallization, we maintain fisetin purity at ≥98% (HPLC) and guarantee the bulk product is free of toxins from Toxicodendron vernicifluum.

2.We remove chlorophyll and impurities from raw materials via refining and purification, resulting in high-purity pale yellow fine crystals with negligible plant odour.

3.In terms of aflatoxins, pesticide residues, PAHs and microbial limits, as well as heavy metal standards of lead, arsenic, mercury and cadmium, our Fisetin meets requirements and well within the statutory limits set by EFSA and FDA (such as Prop 65). 

4.High-purity fisetin monomer is a premium, state-of-the-art fine chemical ingredient. At the project launch phase, overseas clients typically order 1kg-5kg of R&D-grade bulk material for sampling and trial tests. With 14 years of expertise in international fine chemical trading, we are fully versed in customs procedures for non-hazardous goods and use aviation-standard packaging with superior light and moisture resistance. Most importantly, we deliver fast response and seamless customs clearance for both small air shipments and large sea freight consignments.

FAQ

Q1: What is the purity of your Fisetin? And how about its appearance?

A: Our fisetin, an active monomer with HPLC purity of no less than 98%, is refined by multi-stage chromatographic separation and recrystallisation into an exceptionally pure pale yellow crystalline powder with barely any herbal odour. In conclusion, this advantage ensures that when incorporated into premium white creams, fully transparent serums or high grade capsules, it has stable physical and chemical properties and does not alter the colour or odour of finished products.

Q2: As fisetin mostly comes from Anacardiaceae plants, how is the product kept free of urushiol and other harmful allergenic ingredients?

A: At our upstream raw material base, we conduct rigorous selection of smoketree botanicals to completely eliminate harmful allergens. In addition, adopting refined chromatographic separation and recrystallization processes, we guarantee the bulk product is free of toxins from Toxicodendron vernicifluum (such as Urushiol-Free). Most importantly, our product complies fully with safety standards for both oral and topical applications in pharmaceutical-grade materials and premium cosmeceuticals, giving you complete peace of mind during formulation development.

Q3: Why is Fisetin called “King of Senolytics” in longevity?

A: With advancing age, numerous “zombie cells (senescent cells)” that stop dividing yet remain viable, constantly release inflammatory cytokines, and accelerate the ageing of adjacent healthy cells are accumulated in the human body. Scientific study indicates that fisetin is one of the most effective natural senolytic ingredients, especially, its clearance efficiency even surpasses well-known quercetin. Besides, whether taken orally or applied topically, this ingredient induces senescent cell apoptosis, accelerates cell turnover, and is commonly used in high-end compound anti-aging capsules for biological age reversal.

Q4: How does Fisetin work for brain health and relieving brain fog?

A: It triggers major synaptic signaling pathways, supporting the growth and maturation of neuronal synapses. Plenty of reliable research confirms it helps strengthen long-term memory and slow age-related cognitive decline.

Q5: In skincare markets, what is the working principle behind fisetin’s skin anti-aging and repair benefits?

A: Topical use of fisetin removes accumulated senescent skin cells before they impair the dermal collagen structure. This fundamentally lifts sagging skin and fades long-term dullness.