L-Prolinamide
CAS 7531-52-4

Applications

1. As a core chiral scaffold for antidiabetic APIs in DPP-IV inhibitors, L-prolineamide serves as an essential precursor for synthesizing numerous DPP-IV inhibitors across the global pharmaceutical market. Besides, Furthermore, it is also an essential precursor for constructing the active core of anti-diabetic drugs such as Vildagliptin and Saxagliptin.

2.L-prolineamide is a starting material for peptide synthesis. Its structure helps improve the stability and permeability of polypeptide molecules. In artificial polypeptide synthesis, L-prolineamide serves as a special modified group at C-terminus, improving resistance to enzymatic hydrolysis in the human body and extending the efficacy. For this reason, it is widely used in the production of anti-aging polypeptides and therapeutic peptide drugs.

3.In cutting-edge organic synthesis, L-prolineamide and its derivatives,as the popular “small-molecule chiral organocatalysts”,are the important carries for the eco-friendly chemistry and asymmetric synthesis.Featuring the chiral skeleton of the pyrrolidine ring and dual hydrogen-bond donor properties of the amide bond, they exhibit excellent enantioselectivity and diastereoselectivity in catalytic asymmetric aldol reaction, Michael addition, Robinson annulation and other core C–C bond-forming reactions.

Advantages

1.We will strictly control the specific rotation in the range of -104°to -108°, which means the L-configuration is exceptionally pure, and the enantiomeric excess (ee) maintains the value of ≥99.5% , thereby decreasing the the risk of generating ineffective isomers in downstream synthesis.

2.Not only are we testing the assay, but we are also paying more attention to  individual impurity and total impurities. By the multi-step recrystallization technology, we can control the individual impurity in the range of ≤ 0.1%. Besides, the control of moisture and residue on ignition is far stricter than the industry standard to ensure that the products keep perfectly solubility and clarity in organic solvents.

3.We have applied advanced drying technology that effectively prevents the yellowing caused by uneven heating. What’s more, even after a long-distance maritime transport, the product retains its whiteness and fluidity, which demonstrates our strong quality control capability in fine chemicals. Finally, each batch presents as a white, uniform crystalline powder. 

4.In the phase of research and development (R&D), given that L-Prolineamide is required in small quantities and has a relatively high unit price, we will provide 1kg & 5kg aluminium foil vacuum packaging to prevent the materials from absorbing moisture and oxidizing.

FAQ

Q1: What makes L-prolineamide important in the research and develop drugs to effectively switch off diabetes?

A: L-Prolineamide is the key chiral precursor in the synthesis of Dipeptidyl Peptidase-IV (DPP-IV) inhibitors, which provides the specific pyrrolidine ring structure for drug molecules. Because the drug’s bioactivitiy relies especially on its spatial configuration, it can ensure that the synthesised drug molecules possess accurate targeted binding capacity by using the high purity L-Prolineamide.

Q2：How does Shandong Fulibai Chem Co., Ltd. ensure the chiral purity of products?

A: Regarding L-Prolineamide, chiral deviation can lead to loss of drug efficacy, unfortunately, it may even become toxic materials. We will monitor the chiral integrity by testing the specific rotation, and this standard will be strictly controlled within the range of -104° to -108°. Besides, in order to eliminate interference from D-isomers at the source, we ensure the enantiomeric excess (ee) remains≥99.5% during the HPLC test.

Q3:What’s the applications in peptide synthesis?

A: In the research and development of peptide synthesis, L-Prolineamide is usually regarded as building blocks of C-terminal amidated peptides. Compared with the common proline, the amidated structure can not only remarkably improve the stability of peptides in the human body, but it isn’t degraded by protease easily, which is a crucial technical choice when developing high-activity anti-aging peptides and signaling repair peptides.

Q4: Why is Shandong Fulibai Chem Co., Ltd. so strict in controlling the impurity profile?

A: As pharmaceutical intermediates, trace amounts of residual impurities (such as unreacted raw materials or by-products) may interfere the next chemical reactions, resulting in a significant drop in production. Therefore, we will maintain the individual impurity at ≤ 0.1%, and keep total impurities at extremely low levels, which not only meet compliance standards, but also help clients access more highly predictable and purified starting materials for the synthesis of complex, multi-step downstream processes.