L-Asparagine Anhydrous
CAS 70-47-3

Applications

1.It is applied to preparate high concentrations of the pharmaceutical preparations. The molecular weight of the anhydrous substance , which is 132.12 , is approximately 12% lower than the molecular weight of the monohydrate ,which is 150.13, which means at the same weight that anhydride can provide more asparagine molecules. In other words, reducing moisture content creates more space for active ingredients.

2.It is used for moisture-sensitive chemical syntheses that primarily includes organometallic catalysis reactions, strong base reaction systems or specific peptide conjugation reactions.

3.It is used for waterless skincare trends. Because the water of crystallization may cause oil and water to be immiscible, or may lead other active ingredients (such as vitamin C and certain peptides) to be prone to oxidative hydrolysis, oil-based serums, stabilized vitamin C powder or high-activity repair ointments must use anhydride. L-Asparagine Anhydrous can be more readily incorporated into oil phase or the solid system to maintain the long-term stability of formulations.

4.It is used for solid dosage delivery system and a dry powder culture medium. If the  the temperature and humidity are changed, the water of crystallization may trigger a “bridging reaction” leading the powder to cake when monohydrate is stored for a long period. However, anhydrous conditions ensure excellent flowability and redissolubility of the powder.

Advantages

1.Our anhydrous products have a moisture content at ≤0.5%, which ensures that no excess moisture molecules are introduced into moisture-sensitive non-aqueous reaction system or anhydrous skincare formula, thereby safeguarding catalytic activity and formulation stability.

2.We apply special crystallization control technology and moisture-proof vacuum packaging to the powder, remaining excellent flowability and bulkiness even after long-haul sea freight, which improves production efficiency and eliminates the pre-production secondary grinding process for clients.

3.We provide pure anhydrous-grade products with the molecular weight of 132.12. Compared with monohydrate, our product contains over 13.6% active asparagine molecules per gram. If you want high-density, high efficiency, precision formulations and concentrated restorative products, we will provide raw materials with a higher “energy density”.

4.The dehydration process is often accompanied by high-temperature drying, if any slight mishap occurs, it can trigger partial racemization or degradation of amino acids. However, Shandong Fulibai Chem Co., Ltd. ensures that, alongside moisture removal, the chiral purity of L-configurational remains in the range of ≥99% without any residues of thermal degradation products through rigorous monitoring of specific rotation and HPLC impurity profiling.

FAQ

Q1: In formulation research and development, why choose the anhydride rather than the more common monohydrate?

A: The main reason is its moisture sensitivity and efficacy density. In the non-aqueous reaction system, 12% water of crystallization is included in the monohydrate, which will disrupt the reaction environment. Besides, the molecular weight of anhydride (132.12) is so low that it provides approximately 13.6% more active aspartamide molecules than the monohydrate at the same weight. Generally, if you want luxury pharmaceutical formulations with high concentration and small volumes, anhydride is the only precise choice.

Q2: How does Shandong Fulibai Chem Co., Ltd. ensure that the moisture content of anhydrous products truly meets the required standards?

A: We will employ special vacuum low-temperature drying process to keep the moisture content at ≤0.5%. Most importantly, we also deploy XRD (X-ray Diffraction) to monitor crystal form to confirm the material is in a fully anhydrous crystalline state rather than merely being dried. What’s more, precise loss on drying (LOD) test data is provided for each batch to ensure that each gram of raw material always meets the exacting definition of the anhydrous standard.

Q3: Is asparagine anhydrous prone to hygroscopic deterioration during storage?

A: Yes, anhydride has high hygroscopicity, especially when exposed to air, it spontaneously absorbs moisture and then reverts to monohydrate, which leads to a reduction in the percentage of active ingredients. Therefore, Shandong Fulibai Chem Co., Ltd. uses three-layer high-barrier aluminum foil vacuum packaging with an optional nitrogen purging process. Additionally, we recommend that clients should unseal in the dry environment with under class 10,000, and obey the the principle of “use immediately after opening” or “storage after unsealing” to keep its anhydrous properties.

Q4: Does the high-temperature dehydration process affect the chiral purity of L-asparagine (racemization risk)?

A: Inappropriate thermal dehydration can indeed cause partial racemization of amino acids. Therefore, Shandong Fulibai Chem Co., Ltd. employs the accurate temperature profile to ensure the L-configurational is not be destroyed in the dehydration process. Besides, by testing the specific rotation to promise the value remains stably within the range of +34.2° to +36.5°, guaranteeing 100% bioactivity and chiral purity of the product.